个体基因差异与艾滋病的防治

Marrow Transplant And AIDS

本研究室曾在1998年讨论了CCR5用于艾滋病防治的可能性,随后提出了骨髓移植治疗艾滋病的观点。通过移植对HIV具有一定抗性的CCR5-Δ32突变基因型骨髓,能让机体免受HIV侵袭,避免HIV侵入正常细胞内寄生,将有可能使其从艾滋病患者逆向转化成HIV携带者,甚至病毒消失。同时,本研究室还进一步提出了可以有效克服异体骨髓移植弊端的自体骨髓移植疗法,即通过对其自身造血干细胞进行CCR5基因特定体外致突变。最近报道称进行CCR5-Δ32突变基因定向骨髓移植,成功治愈了艾滋病。显然,通过针对CCR5或其它提高HIV抗性的特定靶标的骨髓移植或干细胞基因干预,在HIV防治中有一定的实用价值。

Objective Recently, a report declared that undergoing a transplant of genetically selected CCR5 - △32 mutation bone marrow cured AIDS successfully. In fact, as early as in 2005 we pointed out the possibility of marrow transplantation for the treatment of AIDS in an article in the Journal of Nanhua University （ Medical Edition ）. The transplantation of CCR5 -△32 mutation genotypes bone marrow certain resistant to HIV could theoretically prevent HIV from invading into normal leukocytes, hy which it would be possible to reverse AIDS patients into HIV carriers and even eliminate viruses permanently. At the same time, we further suggested that autologous bone marrow transplantation could effectively overcome the shortcomings of allogenetic bone marrow transplantation via in vitro CCR5 gene - specific mutagenesis of the hematopoietic stem cells from specific patients.