脑脊液β_2微球蛋白检测对病毒性脑炎的诊断意义

Significance of β_2-Microglobul in Cerebrasinal Fluid in Diagnosis of the Viral Meningitis

目的探讨β2微球蛋白(β2-MG)对病毒性脑炎的诊断意义。方法采用免疫比浊法测定63例病毒性脑炎患者和12例对照组脑脊液中β2-MG水平。病脑组采集第7、14天的脑脊液标本进行动态分析。结果病脑组脑脊液中β2-MG在入院时及第7、14天显著高于对照组(P<0.01),第14天与对照组比较无明显差异(P>0.05)。结论病毒性脑炎患者脑脊液中β2-MG增高,检测脑脊液中β2-MG水平有助于病毒性脑炎的诊断。

Objective To investigate the variation tendence and the clinical diagnostic value of β2- microglobulin （β2-MG） in the viral meningitis （VM）. Methods The levels of β2 - MG in CSF of 63 viral meningitis ease and 12 subjeers in control group were measured by immunoturbidimetry, and the CSF sample of the VM were collected at 7,14 day. Results The level of β2 - MG in CSF at admission at 7th day was significantly higher in the VM group compared with the control group（P 〈0.01）. And at 14th day, that of β2 - MG in VM group has no difference from the control group （ P 〉 0.05）. Conclusion β2 - MG was increased in the CSF of patients with VM. The level of β2 - MG in CSF may be a valuable index in diagnosis of the VM.