磷氮霉素的研究进展及应用前景

Study Progress and Applying Prospect of Phoslactomycins

磷氮霉素是由链霉菌产生的具有抗真菌、抗肿瘤活性的一类多组分聚酮类化合物,因分子中含有磷酸基和氨基而得名。它们是蛋白磷酸化酶2A的选择性抑制剂,有发展成为抗肿瘤先导化合物或抗真菌生物农药的潜力。磷氮霉素类化合物具有独特的化学结构,其平面化学结构包含α、β-不饱和内酯、磷酸酯、共轭二烯和环己烷等基团。在不同链霉菌中发现的磷酰周霉素、磷酰霉素和leustroducsins等化合物与磷氮霉素具有相似结构,它们之间的差别仅在于C-18位羟基上的酰基基团不同。本文就磷氮霉素的发现、结构鉴定、生物活性及应用前景等作一综述。

Phoslactomycins,named after the phosphate group and amino-group in the moleculars,are a class of polyketide antifungal and antitumor antibiotics produced by many Streptomyces.As the selective inhibitor of protein phosphorylase 2A,they have the potential for the antineoplastic drugs or antifungal biopesticides.Phoslactomycins represent an unusual structural class of natural products secreted by various streptomycetes,containing an α,β-unsaturated-lactone,an amino group,phosphate ester,conjugated diene and a ...