2型糖尿病患者腰围身高比值与颈动脉内膜中膜厚度相关性分析

Relationship between waist to height ratio and carotid intima-media thickness in type 2 diabetes patients

目的探讨腹型肥胖指标腰围身高比值（WHtR）与2型糖尿病患者颈动脉内膜中膜厚度（IMT）的关系。方法117例住院2型糖尿病患者，以WHtR0．50为切点分为A组（WHtR〈0．50）42例和B组（WHtR≥0．50）75例，分析wHtR与IMT的关系。结果B组体质量指数（BMI）、腰围、胰岛素抵抗指数（HOMA—IR）和IMT均高于A组，BMI 28．41±2．40 vs 21．20±2．60、腰围（95．92±8．71）mm vs （74．91±6．30）mm、HOMA—IR 1.67±0．65 vs 0．85±0．70、IMT（0．89±0．10）mm vs（0．81±0．14）mm。多元线性回归分析显示WHtR是IMT的独立危险因素[偏回归系数（8）=0．072，t=4．808，P=0．000]。logistic回归分析显示wHtR≥0．5者发生IMT增厚的危险是WHtR〈0．5者的3．720倍（95％CI=1．391～9．948，Wold X^2值=6．854，P=0．009）。结论wHtR与IMT密切相关，可作为预测IMT增厚的简便身体测量指标。

Objective To evaluate the relationship between waist to height ratio（WHtR） and carotid intimamedia thickness（IMT） in type 2 diabetes patients. Methods The study included 117 diabetes in-patients, who were divided into two groups： A group（WHtR〈0.50, n = 42） and B group （WHtR≥0.50, n = 75）. The relationship between WHtR and IMT was analyzed. Results B group had significantly higher levels of body mass index （BMI）, waist circumference, HOMA-IR and IMT than A group（ P 〈0.05）, BMI 28.41±2.40 vs 21.20±2.60, waist （95.92±8.71） mm vs （74.91±6.30） mm, HOMA-IR 1.67±0.65 vs 0.85±0.70 and IMT （0.89±0.10） mm vs （0.81±0.14） mm. Multiple linear regression analysis showed that WHtR was a significant independent predictor for IMT（β= 0. 072, t = 4. 808, P=0. 000）. Odds rations of the thickening of carotid artery IMT in B group was 3. 720 times（95% CI=1. 391-9. 948, P =0.009） against A group. Conclusion IMT is associated with WHtR and can serve as a measure of abdominal fat accumulation,WHtR may be a useful predictor of IMT.