厄贝沙坦/氢氯噻嗪治疗轻中度高血压左心室肥厚疗效观察

The investigation of the curative effect of irbesartan/hydrochlorothiazide combination on the mild to moderate hypertension patients with left ventricular hypertrophy

目的:探讨厄贝沙坦/氢氯噻嗪片治疗轻中度高血压左心室肥厚(left ventricular hypertophy,LVH)的疗效。方法:采用自身对照试验,轻中度高血压患者经超声心动图检查证实LVH78例,厄贝沙坦/氢氯噻嗪片口服,每日1次晨服2片,疗程3个月。治疗前后彩色超声多普勒检测左室相关数据,计算左心室质量指数(LVMI),分析治疗前后LVMI指数及心功能参数变化。结果:治疗后收缩压与舒张压明显下降(P<0.001)。左心室舒张末期内径、左心室后壁与室间隔厚度显著下降(P<0.001),左心室质量及LVMI指数下降更显著(P<0.001)。结论:轻中度高血压患者在厄贝沙坦/氢氯噻嗪片治疗3个月后可显著逆转LVH,同时使左心室舒张功能显著改善,安全有效。

Objective： To investigate the curative effect of irbesartan/hydrochlorothiazide combination on the mild to moderate hypertension patients with left ventricular hypertrophy. Methods：By using self control, the 78 cases of mild to moderate hypertension with left ventricular hypertrophy were confirmed by eehocardiograpby, then they were treated with irbesartan/hydrochlorothiazide combination orally two pieces once a day in the morning, and it was lasted for three months. The correlated data of left ventricle were tested by muhieolor hyperacoustic Doppler before and after treatment. The left ventricular mass index（LVMI） was calculated and the changes of the LVMi and heart function parameters were analysed. Results：The systolic pressure and diastolic pressure were decreased significantly after treatment （ P 〈 0. 001 ）. The inner diameter of the left ventricular end-diastole, the thickness of the posterior left ventricular wall and the interventricular septum were decreased significantly（P 〈 0. 001 ）. The left ventricular quality and LVMI were decreased more significantly（ P 〈 0. 001 ）. Conclusions ： After three months treatment of irbesartan/hydrochlorothiazide combination, the symptom of left ventricular hypertrophy was significantly reversed in the mild to moderate hypertension patients, meanwhile the diastolic function of left ventricle was improved. It is securely and effectively.