肥胖、脂毒性与心力衰竭

Obesity,Lipid Toxicity and Heart Failure

肥胖中脂肪组织扩张到最大限度后脂质溢出,非脂肪组织如心脏等也出现了脂质累积。心脏由最初代偿性改变,而后出现脂毒性状态,最终出现收缩功能不全。非酯化脂肪酸的过度供应加上代谢失调(包括脂肪酸不充分的氧化)导致线粒体功能不全是发病过程中的一个重要环节。

Fatty tissue expands to a maximum extent in obese individuals,allowing lipids to accumulate in non-fatty tissue such as the heart.Thus,an oversupply of nonesterified fatty acids,together with metabolic dysregulation in obesity,and an inadequate activation of fat oxidation,results in mitochondrial dysfunction,which plays a vital role in the mechanism of obesity related heart failure.