易损血液与动脉粥样硬化症关系研究进展

Progression of Relationship Between Susceptible Blood and Atherosclerosis

研究表明动脉粥样硬化是在内皮损伤、脂质代谢异常、血流动力学损伤、遗传、感染、物理化学等损伤刺激下启动的,多种炎症因子、免疫机制及相关细胞因子网络交叉样作用于血管壁,动脉粥样硬化逐渐形成和发展同时伴随不稳定斑块的破裂、血栓形成,导致慢性和急性缺血或闭塞性临床事件。不论何种机制,血管壁动脉粥样硬化必须通过血液来介导和促进,易损血液包括血液的成分和状态异常,血液易损程度与动脉粥样硬化性临床事件正相关。

Under the stimulation of endothelium injury, abnormality of lipid metabolism, hemodynamic injury, heredity, inflammation and physical chemistry, athcrosclerosis of blood vessel can be informed by the effects of many kinds of inflamintory factors, immunologic meehnism and cytokines. Thrombogenesis of the unstable atheroslerosis results in ischemic or obstructive clinical incidents. Regardless of any mechanisms, atherosclerosis of vessel wall must be mediated by susceptible blood. Susceptible blood includes components and state abnor- mality. There is a positive correlation between susceptible degree of blood and atherosclerotic clinical incidents.