空腹血糖调节受损合并冠心病冠脉造影特点分析

Analysis of characteristics of coronary angiography of coronary heart disease accompanying with impaired fasting glucose tolerance

目的了解空腹血糖调节受损(IFG)患者的相关代谢特点、冠心病患病情况及冠状动脉造影特点。方法回顾分析2005～2007年在本院疑诊冠心病住院的392例患者的临床相关资料及冠脉造影结果。结果(1)糖尿病组(DM)总胆固醇显著高于正常血糖组(NGT)、IFG组(P<0.05),三酰甘油、低密度脂蛋白、高密度脂蛋白、尿酸、高血压病在3组间差异均无统计学意义(P>0.05)。(2)NGT、IFG、DM组冠脉造影阳性率分别为56.5%、78.3%、91.4%;IFG、DM组冠心病患者冠脉病变以三支及弥漫血管病变为主。IFG、DM组冠心病患者冠脉狭窄总积分高于NGT组,且冠脉以极重度狭窄为主。(3)logistic回归分析示IFG是冠心病发生危险因素,Spearman秩相关示空腹血糖与冠脉病变程度积分呈正相关。结论空腹血糖调节受损与冠心病发生及其冠脉病变程度密切相关。

Objective To understand features of coronary angiography（CAG） ,metabolic characteristics and prevalence of coronary heart disease（CHD） in patients with CHD accompanying impaired fasting glucose toleranee（IFG）. Methods The clinical information and results of CAG of 392 suspected CHD patients in our hospital between 2005 to 2007 were retrospective analysed. Results （1）The level of total cholesterol （TC） was significantly higher in diabetes mellitus group（DM） than normal glucose tolerance group （NGT） and IFG group. There were no significantly difference in the levels of triglycerides （TG） ,low-density lipoprotein （LDL） ,high-density lipoprotein （HDL）, uric acid （UA） and essential hypertension （EH） among NGT, IFG and DM Group. （2） The positive rates of CAG of oNGT, IFG and DM group were 56.5 %, 78.3 %, 91.4 %, respectively. The coronary lesions of IFG/DM group patients were more diffused,and had a higher total score of coronary stenosis than NGT group. The stenosis degree of coronary lesions of IFG/DM group were very severe. （3）IFG was a risk factor for coronary heart disease from logistic regression analy- sis,and FPG was positively correlated with total score of coronary stenosis by Spearman correlative analysis. Conclusion IFG is closely related with CHD and its stenosis degree.