老年高血压患者血尿β_2微球蛋白变化及其在肾损害中的意义

Study of β_2-MG Hematuria in Patients with Hypertension and its Clinical Significance of Renal Injury Research

目的:观察老年高血压患者血尿β2微球蛋白(β2-MG)的变化,探讨血尿β2微球蛋白(β2-MG)在早期诊断老年高血压患者肾损害中的意义。方法:采用放射免疫法(RIA)对老年高血压患者142例(高血压Ⅰ期50例,Ⅱ期52例,Ⅲ期40例)的血尿β2-MG测定,以正常老年人44例作为对照。结果:高血压Ⅰ期组β2-MG较正常升高(P<0.05),Ⅱ期组、Ⅲ期组患者血尿β2-MG均明显升高(P<0.01)。结论:测定血尿β-MG对早期诊断老年高血压肾损害有一定的参考价值。

Objective:To explore the change of urine β2-microglobulin(β2-MG) in elderly patients with hypertension and its significance in the early diagnosis of renal damage in elderly hypertension.Methods:radioimmunoassay(RIA) of 142 cases of elderly patients with hypertension,44 cases of normal elderly β2-MG determination of hematuria.Results:Ⅰ period of high blood pressure group than normal β2-MG increased(P<0.01),Ⅱ period,Ⅲ period hematuria β2-MG were increased(P <0.01).Conclusions:Early determination of urine β2-MG has a referencial value in the early diagnosis of renal damage in elderly hypertension.