c-met癌基因在乳腺癌增殖及血管生成中的作用

The Role of Oncogene c-met in Tumor Proliferation and Angiogenesis in Breast Cancer

目的:探讨原癌基因c-met在乳腺癌增殖及微血管生成中的作用,为临床乳腺癌的病情预测及预后判断提供新的实验依据。方法:通过S-P免疫组织化学方法和微血管密度计数(MVD),检测75例乳腺浸润性导管癌和20例乳腺纤维腺瘤组织中原癌基因c-met的表达情况和微血管密度。结果:乳腺癌组织c-met阳性表达与组织学分级、淋巴结转移、肿瘤分期显著相关(P<0.05),而与年龄、病变部位、月经情况、雌激素水平、孕激素水平、肿瘤大小无关(P>0.05)。微血管计数与c-met阳性表达显著相关(P<0.01)。结论:c-met癌基因在乳腺癌中表达增强与乳腺癌肿瘤细胞增殖状态及微血管生成直接相关,可以成为判断乳腺癌预后的一个有价值的指标。

Objective：To find the role of prooncogene c-met in tumor proliferation and angiogenesis in breast cancer so as to provide the theory of the possibility of a new prognosis prediction for breast careinorma. Methods：By using immunohistochemical method and MVO（microvessel density）, c-met protein expression and microvessel density were measured in 75 cases of breast carcinoma and 20 cases of breast fibroadenoma. Results：The expression of c-met in breast carcinoma tissues were significantly correlated with histologic grade, lymph node metastasis and tumor stage （P〈0.05） , but it was insignificantly correlated with ages, lesion position, menopausal status, ER and PR, tumor size （P〉 0. 05）. Positive rate of c-met expression was significantly correlated with microvessel count（P〈0. 01）. Conclusion： Prooneogene c-met was closely related with tumor proliferation and tumor angiogenesis. It could be one of valuable prognosis indicators in breast cancer.