生活方式与绝经后骨质疏松症发病风险的关系

Life Style and the Risk of Postmenopausal Osteoporosis

目的探讨生活方式(包括体力活动、饮食习惯等)与绝经后骨质疏松症(PMOP)发病风险的关系。方法根据纳入和排除标准,经双能X线吸收法(DXEA)测定腰椎骨密度并确诊后,对220名绝经后妇女进行危险因素的回顾性调查。基于单因素分析结果并结合专业依据确定了27个因素进行非条件Logistic逐步回归分析,以OR值与95%CI反映与疾病危险性的关联程度。结果对照组在经常喝豆浆、日照时间、参加体育锻炼、肉蛋类膳食为主方面的情况明显多于病例组(均P<0.05)。锻炼方式中,步行、力量练习、太极拳、健身舞蹈、爬楼梯这几种运动方式在两组之间差异有统计学意义(均P<0.05)。经混杂因素校正后,总体力活动和交通行程性体力活动水平得到活跃、跳健身舞蹈、青少年时期爱好体育运动、经常喝豆浆、肉蛋类膳食为主对PMOP发病风险的影响仍然存在,是PMOP的保护因素。结论生活方式与PMOP发病风险有关。总体力活动和交通行程性体力活动水平活跃、跳健身舞蹈、经常喝豆浆、肉蛋类膳食为主、青少年时期爱好体育运动均可降低PMOP发病风险。

Objective To investigate the association between life style and the risk of osteoporosis in postmenopausal women.Methods In a retrospective investigation comprising 220 postmenopausal women,an interviewer-administered questionnaire was utilized to retrospectively assess the risk of postmenopausal osteoporosis（PMOP）.Bone mineral density at the lumbar spine was assessed by dual-energy X-ray absorptiometry（DXEA）.Chi-square test was used to compare differences between cases and controls.Unconditional logistic regression was applied to estimate odds ratios and 95% confidence intervals.Results After adjusting for confounding variables,physically active in PA（both in total and transportation）,health-enhanced dance,drinking soybean milk,were protective factors.Women reported doing exercise during teenagers was less likely to experience PMOP.Health-enhanced dance was an effective way for postmenopausal women to prevent PMOP.Conclusion Life style may probably affect the risk of PMOP.PA in transportation and the total significantly decreased the risk of PMOP.