摘要
目的确定肝脾康颗粒的最佳制粒处方组成。方法以颗粒吸湿百分率、成型率和溶化率为指标,筛选颗粒的最佳辅料与配比。结果处方最佳组成为3份浸膏粉与3份辅料(蔗糖∶糊精=2∶1的混合辅料);所制颗粒的吸湿率小、成型率高、溶化率高。结论试验结果可为肝脾康颗粒制剂处方组成的确定提供依据。
Objective To ascertain the best granulation formulation process of Ganpikang Granule. Methods By determining hygroscopicity, granulation and dissolubility as the indexes, the optimal excipient and its formula were screened. Results The best excipient and its formula were three extract powders and three excipients which consisted of sucrose and dextrin (2:1, W/W). The made granules had low hygroseopicity, high granulation and high dissolubility. Conclusion The experimental results provide the basis of the ascertainment of formulation orocess and the control of production environment of Ganoikang Granule.
出处
《中国药业》
CAS
2009年第19期41-42,共2页
China Pharmaceuticals
关键词
肝脾康颗粒
成型工艺
临界相对湿度
Ganpikang Granule
formulation process
critical relative humidity