摘要
目的优化清咽口含片的处方设计。方法以体外溶出度及外观、硬度、片重差异的综合评分为考察指标,采用正交设计法优化处方。结果口含片最佳处方为甘露醇125g、木糖醇125g、乳糖90g。结论清咽口含片的处方设计和制备工艺合理。
Objective To optimize the prescription of Qingyan buccal tablets.Methods The optimizztion experiment was performed with a orthogonal design with the formula ratio of several excipients as affecting factors, evaluation index of the experiment was the invito dissolution, hardness and appearrance characteristics. Results The optimized prescription was composed of follows: 125g mannitol, 125g xylito 160g lactose. Conclusions The formulation of Qingyan buccal tablets and preparative technology was reasonable.
出处
《国际医药卫生导报》
2009年第18期4-7,共4页
International Medicine and Health Guidance News
基金
广尔医学院基金会资助课题(0502)
关键词
清咽口含片
制备工艺
正交设计
金银花
溶出度
Qingyan buccal tablets
Preparative technology
Orthogonal design
Honeysuckle
Dissolution