应激性高血糖及糖尿病患者糖化血红蛋白的临床研究

Clinical Research on Glycated Hemoglobin of Stress Hyperglycemia and Diabetes

目的:探讨糖化血红蛋白(HbAlc)检测在应激性高血糖以及糖尿病患者中的临床价值及意义。方法:在伯乐BIO-RAD D-10糖化血红蛋白系统上使用高压液相层析法(HPLC)对我院住院患者中测得高血糖者以及糖尿病患者进行HbAlc测定,并追踪血糖状态最终诊断,对于HbAlc低于正常者加测多时间段血糖,进行临床分析。结果:糖尿病高血糖者HbAlc9.85±1.22%,应激性高血糖者HbAlc7.64±1.25%,糖尿病低血糖者HbAlc3.56±1.11%。经t检验,应激性高血糖者与糖尿病高血糖HbAlc有显著性差异(P<0.01)。结论:HbAlc可以作为应激性高血糖与糖尿病高血糖鉴别诊断的简单、有效的方法推广应用。HbAlc检测有利于发现夜间及无症状低血糖,有利于监测和诊断糖尿病持续、稳定、安全达标。

Objective： To explore the clinical significance of glycated hemoglobin in n-eating stress hyperglycemia and diabetes. Methods： The content of glycated hemoglobin of inpatients with diabetes and high blood glucose was determined by high-pressure liquid chroma- tography（HPLC） based on Bio-Rad D-10 glycated hemoglobin systems. And the final diagnosis was tracked. For cases with lower level of glycated hemoglobin, further determination was carried out. Results：The average content of glycated hemoglobin in patients as diabetes with high blood glucose was 9.85 ± 1.22. And for stress hyperglycemia, 7.64 ± 1.25 ; for diabetes with hypoglycemia, 3.56 ± 1.11. There had significant difference of glycated hemoglobin between group of stress hyperglycemia and that of diabetes with high blood glucose （ P 〈 0.01 ）. Conclusion： The determination of glycated hemoglobin can be used as a simple, effective index of differential diagnosis between stress hyperglycemia and diabetes with high blood glucose.