检测CEA和CA_(125)在腹水患者中的临床意义

Analyzing the Clinical Significance of Determining CEA and CA125 in Patients with Hydroperitoneum

目的:研究良、恶性腹水表达癌胚抗原(CEA)和糖类抗原(CA125)的差别,以提高对肿瘤诊断与病性判断的准确性。方法:研究对象包括恶性腹水患者58例、良性腹水患者63例,收集血清腹水为检测标本,应用电化学发光免疫测定技术(ECLIA)检测CEA、CA125。结果:恶性腹水组腹水CEA、CA125均明显高于良性腹水组(P<0.01),恶性腹水组血清CEA显著高于良性腹水组(P<0.05)。联合检测CEA和CA125可提高恶性腹水的检出敏感性。结论:联合检测血清和腹水中CEA和CA125有助于鉴别良恶性腹水,并可提高恶性腹水的检出率。

Objective： To explore the differences of carcinoembryonic antigen （CEA） and CA125 expressed in benign and malignant hydroperitoneum, improve the accuracy of tumor diagnosis. Methods： 58 cases of malignant hydroperitoneum and 63 cases of benign hydroperitoneum were collected. Quantity of CEA and CA125 in serum and hydroperitoneum was determined by electrochemiluminescence immunoassay（ECLIA）. Results：Quantifies of CEA and CA125 in hydroperitoneum of group of malignant hydropefitoneum are obviously higher than those of group of benign （P〈0.01）, and the quantifies of CEA in serum of group of malignant are higher than those of group of benign（P 〈 0.05）. Conclusion： It is helpful to determine CEA and CA125 in serum and hydropefitonetrrn for differential diagnosis on benign and malignant hydroperitoneum, which is a sensitive method to diagnose malignant hydroperitoneum.