慢性阻塞性肺疾病与细胞黏附因子2和尾加压素Ⅱ的关系及意义

The Relation and Significance of between Chronic Obstructive Pulmonary Disease and Intercellular Adhesion Molecule and Urotensin

目的探讨细胞黏附因子2(ICAM-2)和尾加压素Ⅱ(U-Ⅱ)在慢性阻塞性肺疾病发病中的意义。方法用酶联免疫吸附法(ELISA)定量检测56例COPD患者和50例正常健康人血浆中ICAM-2和U-Ⅱ含量。结果ICAM-2和U-Ⅱ在患者及健康人中均有表达,COPD组分别为(20.70±7.20)、(2.50±1.62)μg/L,而健康人分别为(18.75±5.10)、(1.61±1.05)μg/L,COPD组明显高于对照组,差异有统计学意义(P<0.01)。结论COPD患者血浆中ICAM-2和U-Ⅱ升高,它们可能在慢性阻塞性肺疾病的发展过程中起着重要的作用。

：Objective To investigate the significance and relation between chronic obstructive pulmonary disease（COPD） and intercellular adhesion molecule-2（ICAM-2） and urotensin- Ⅱ （U-Ⅱ）. Methods Plasma were obtained from patients and healthy people, ICAM-2 and U- Ⅱ in plasma were both measured by ELISA. Results ICAM-2 and U- Ⅱ expressed in patients and healthy people, their concentration were respectively （ 20.70 ±7.20 ）, （ 2.50 ± 1.62 ） and （ 18.75 ±5.10 ）, （ 1.61± 1.05 ） μg/L. The concentration of ICAM-2 and U-Ⅱ were higher than that in controls, there were significant difference（ P 〈 0.01 ）. Conclusion The levels of ICAM-2 and U- Ⅱ in the patients of COPD are increased, indicate they may play an important role in the development of COPD.