摘要
以D-苏氨酸为起始原料合成头孢拉宗.D-苏氨酸为起始原料,经甲硅烷化后与4-乙基-2,3-二氧-1-哌嗪甲酰氯缩合制得侧链酸,再与7-TMCA缩合、C7位引入甲氧基得到头孢拉宗.目标化合物经核磁共振氢谱确证其化学结构.该合成方法工艺简单,反应效率提高.
To synthesize cefbuperazone,D-threonine was used as starting material.D-threonine was acylated by monosilane,acylate with4-Ethyl-2,3-dioxo-1-piperazine carbonyl chloride were condensed to obtain ATBA.Then ATBA was condensed with 7-TMCA,7-methoxylation to generate cefbuperazone.The structure of cefbuperazone was verified by 1H-NMR.The findings show that this method is simple and has higher chemical efficiency.
出处
《成都大学学报(自然科学版)》
2009年第3期199-201,共3页
Journal of Chengdu University(Natural Science Edition)