期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

头孢拉宗的合成 被引量：4

Synthesis of Cefbuperazone
下载PDF
导出
摘要 以D-苏氨酸为起始原料合成头孢拉宗.D-苏氨酸为起始原料,经甲硅烷化后与4-乙基-2,3-二氧-1-哌嗪甲酰氯缩合制得侧链酸,再与7-TMCA缩合、C7位引入甲氧基得到头孢拉宗.目标化合物经核磁共振氢谱确证其化学结构.该合成方法工艺简单,反应效率提高. To synthesize cefbuperazone,D-threonine was used as starting material.D-threonine was acylated by monosilane,acylate with4-Ethyl-2,3-dioxo-1-piperazine carbonyl chloride were condensed to obtain ATBA.Then ATBA was condensed with 7-TMCA,7-methoxylation to generate cefbuperazone.The structure of cefbuperazone was verified by 1H-NMR.The findings show that this method is simple and has higher chemical efficiency.
作者 慈志敏 付超美 崔名全 周绚
机构地区 成都中医药大学药学院
出处 《成都大学学报（自然科学版）》 2009年第3期199-201,共3页 Journal of Chengdu University（Natural Science Edition）
关键词 头孢拉宗 D-苏氨酸 合成 Cefbuperazone D-threonine synthesis
分类号 R914.5 [医药卫生—药物化学]
  • 相关文献

参考文献4

  • 1Shuntraro Takano, lsamu Takakura, Hirokazu Ochiai. Studies on β-Lactam Antibiotics for Medicinal Purpose [J]. Yak-Ugaku Zasshi, 1982, 102(7) :629 - 645.
  • 2Isamu Saikala, Shuntraro Takano, Hiroyuki Imaizumi. 7-Methoxycephalosporins andpharmaceutical composition comprising the same [P]. US4263292,1981.
  • 3Mintz M J,Walling C. t-Butyl Hypochlorite [J]. Organic Syntheses Coll, 1975,5(11) : 184 - 185.
  • 4Koppel G A,Koehler R E. Function-alization of C6(7) of Penicillins and Cephal-osporin. A One-Step Stereoselective Synth-esis of 7-α-Methoxycephalosporin C[J]. Journal of the American Chemical Society, 1973,95(7) :2403 - 2404.

同被引文献28

  • 1Takano S,Takakura I,Ochiai H,et al.Studies on beta-lactam antibiotics for medicinal purpose.ⅩⅢ.Synthesis and structure-activity relationships of 7 beta-[alpha-(4-alkyl-2,3-dioxo-1-piperazinecarboxamido)-alpha-substituted acetamido]-7 alpha-methoxycephalosporanic acids.Yakugaku Zasshi,1982,102(7):629-645.
  • 2Taki H,Yasuda T,Ochiai H,et al.7-alpha-methoxycephalosporins and pharmaceutical composition comprising the same:US,4263292.1981-04-21.
  • 3Clinical and Laboratory Standards Institute.Performance standards for antimicrobial susceptibility testing; sixteenth informational supplement.2006,26(3).M100-S16.
  • 4Clinical and Laboratory Standards Institute.Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically;approved standard-seventh edition.2006,26(2):M7-A7.
  • 5Shuntraro T, Isamu T, Hirokazu O. Studies on β - lactam antibiotics for medicinal purpose [ J ]. Yakugaku Zasshi, 1982; 102: 629 - 645.
  • 6Isamu S, Shuntraro T, Hiroyuki I. 7 - Me - thoxycephaLosporins and pharmaceutical composition comprising the same [ P ]. US: 4263292,1981-04 -21.
  • 7Mintz M J, Walling C. t - Butyl hypochlorite [ J ]. Org Synth Coil, 1975 ; 5:184 - 185.
  • 8Neu HC, Chin NX, Labthavikul P. The activity of cefbuperazone, a 7 alpha - methoxy 7 beta acyl ureido cephalosporin [ J ]. Chemioterapia, 1985 ; 4 : 415 - 423.
  • 9Khan NJ, BihL JA, Schell RF, et al. Antimicrobial activities of BMY-28142, cefbuperazone, and cefpiramide compared with those of other cephalosporins [ J ]. Antimicrob Agents Chemother, 1984 ; 26 : 585 - 590.
  • 10Kameyama J, Tsukamoto M, Asano T, et al. Experimental studies on the pharmacokinetics and therapeutic effect of cefbuperazone in biliary infection[J]. Curr Med Res Opinion, 1989; 11 : 576 -584.

引证文献4

二级引证文献6

成都大学学报（自然科学版）
2009年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部