硫酸卷曲霉素注射液在复治涂阳肺结核中的临床应用

Analysis of Therapeutic Effects of capreomycin sulfate on Retreatment Smear Positive Pulmonary Tuberculosis

目的:观察硫酸卷曲霉素静脉滴注在复治涂阳肺结核中的临床应用。方法:根据有关标准选取复治涂阳肺结核219例,随机分为两组:试验组硫酸卷曲霉素0.75g静脉滴注qd×2个月;对照组硫酸链霉素0.75g肌肉注射qd×2个月,同时辅以其它抗痨药。结果:试验组和对照组2月末与8月末痰菌阴转率差异有显著性,8月末X线阴影好转率亦有显著性差异,但8月末空洞闭合率差异无显著性。毒副作用发生率对照组(40%)较试验组(33.8%)稍高,尤其是注射局部疼痛硬结较为多见。结论:硫酸卷曲霉素对复治肺结核涂阳病例痰菌阴转效果显著。

Objectives： To observe and evaluate the therapeutic effects of capreomycin sulfate on retreatment smear positive pulmonary tubereulosis. Methods： 219 cases of retreatment pulmonary tuberculosis with bacteriological positive were divided into treatment group and control group. The former group was treated by capreomycin sulfate, and the control group was treated by streptomycin sulfate and other second-line antituberculosis drugs. The treatment course of capreomycin sulfate and streptomycin sulfate was 2 months. Results： By the end of second and eighth months, the difference of sputum negative conversion rates between treatment group and control group was significantly high. After eight months the improvement rates of the two groups were also significant , but the rates of close-up of cavity had no significant difference. Side effects of the control group was higher than that of the treatment group. Conclusions. Therapeutic effects of capreomycin sulfate on retreatment smear positive pulmonary tuberculosis was remarkable.