异时性多原发性结直肠癌十例临床分析

Metachronous multiple primary colorectal carcinomas：an analysis of 10 cases

目的探讨异时性多原发性结直肠癌的临床病理特点、诊治及预后。方法回顾分析我院2003年至2007年间收治的10例异时性多原发性结直肠癌患者的临床资料、病理及随访资料。结果异时性多原发性结直肠癌病例占同期所有收治结直肠癌的1．2％（10／814），平均间隔时间3．55年，均经肠镜检查发现，9例行根治性切除，1例行姑息手术，再发癌以Dukes B期多见。结论异时性多原发性结直肠癌临床病理学特点突出，应注意重视肠镜检查，加强手术后随访有助于异时性多原发性结直肠癌的发现和诊断，提高预后。

Objective To explore the clinicopathological characteristics and prognosis of multiple primary colorectal carcinoma. Method The clinical data of 10 patients with metachronous multiple primary carcinoma of the colon and rectum （ MMPCCR ）who were treated in our hospital from 2003 to 2007, were retrospectively analyzed. Results The percentage of patients with MMPCCR was 1.2% （10/814） and the average interval was 3.55 years. All cases were diagnosed by colonoscopy. Radical resection was performed on 9 cases, and palliative resection on 1 case. Stage of Dukes B was common in the most of the second carcinoma. Conclusion MMPCCR has particular clinical and pathological characteristics. Colonoscopy is important in the diagnosis of MMPCCR. Postoperative follow-up should be strengthened for the early diagnosis of MMPCCR for the better prognosis.