穿心莲质量控制的再评价

Re_evaluation of Quality Control of Andrographis paniculata

穿心莲叶质量评价的主要指标应该是穿心莲内酯，由于该成分随贮存时间延长或处理不当而降低，导致市场商品穿心莲内酯含量很低。中国药典规定的药用部分、采收时间及质量控制指标均有不当之处，执行中发现新采收穿心莲叶因穿心莲内酯含量高反而不合格，造成误导。建议新版药典作适当修订，药用部分改为叶，采收时间改为开花期。

Andrographolide,the active diterpene lactone in Folium Andrographitis, is the main content for quality evaluation.However, the content of andrographolide in the leaves decreases gradually and that of another terpene lactine, dehydroandrographolide, increases during long storage in an open environment. So the longer the storage time, the lower the quality will be. It seems irrational that the content for its quality control is not andrographolide but dehydroandrographolide in the Chinese Pharmacopoeia of 1995 edition.Judged by such stipulation, the freshly collected leaves would be substandard. According to the research and the literature published elsewhere, it is suggested that the assay should be revised in the edition of 2000. Andrographolide should be the index for the content determination of Andrographis paniculata, the collecting period should be revised as flowering and the part used for medicine be leaves without stems.