持续性植物状态(PVS)动物模型的研制(论著)

The investigation and establishment of the animal model of persistent vegetative state(PVS)

目的：建立持续性植物状态的动物病理模型。方法：用１８０只新西兰家兔，切除其大脑皮层Ｂｒｏｄｍａｎｎ氏１、２、３、４、５、６、７、２３、２４以及部分３２及５０区。结果：以上手术后的动物在多种生理指标、反射活动、高级神经系统功能活动、昼夜节律以及大脑神经病理学的变化各主要表现方面与临床ＰＶＳ患者十分相似或一致。结论：本实验所建立的动物模型的表现与一般临床ＰＶＳ患者的症状及鉴定标准内容一致。

Aim:To establish a pathological model of persistent vegetative state(PVS).Methods:180 New Zealand rabbits were used,and the Brodmann's 1,2,3,4,5,6,7,23,24 areas and partial 32,50 areas of the animal's cerebral cortex were excised.Results:After the excision operation,the changes of physiological indices,reflex activities,high function activities of the central nerve system,circadian sleep wake cycle and also the pathohistological changes of the brain were very similar with that of clinical PVS patients.Conclusion:The presentations in many aspects of the animal model established in this experiment is in accordance with the symptoms and diagnostic criteria of clinical PVS patients.