高压氧对I型变态反应及免疫功能的影响(论著)

Effect of hyperbaric oxygen on type I allergic reaction and immune function

目的：探讨高压氧（ＨＢＯ）对Ⅰ型变态反应及一些免疫功能指标的影响。方法：将实验动物（大鼠，小鼠，兔）分为对照组和ＨＢＯ组（ＨＢＯ处理５天或１０天），ＨＢＯ处理为每天在０．２５ＭＰａ（２．５ＡＴＡ）压力下吸９９．２％氧２小时。然后各组分别观察测定Ⅰ型变态反应及免疫功能几项指标的改变，并进行组间比较分析。结果：ＨＢＯ处理可以减轻大鼠同种被动皮肤过敏反应和小鼠的异种被动皮肤过敏反应，还可以抑制干酪素引起的小鼠肥大细胞脱颗粒反应。在免疫功能方面，ＨＢＯ处理使家兔末梢血Ｔ淋巴细胞数明显下降，小鼠抗体形成细胞数目明显减少。结论：在本实验条件下，ＨＢＯ处理可防止或减轻动物Ⅰ型变态反应的发生，同时对细胞免疫功能和体液免疫功能也有显著的抑制作用。

Aim:To explore the effect of hyperbaric oxygen(HBO)on type Ⅰ allergic reaction and some indexes of immune function.Methods:Test animals(rats,mice,rabbits)were devided into the control group and HBO groups(HBO treatment for 5 or 10 days).The HBO treatment was pure oxygen(99 2%)inhalation for 2 hours each day under 0.25 MPa abs pressure.Then the evidence of type Ⅰ allergic reaction and changes of some immune function indexes were observed and measured in these groups and were comparatively analyzed.Results:HBO treatment could alleviate both the rat homo passive skin allergic reaction and the mice hetero passive skin allergic reaction;it could also inhibit the tyroxin induced mice mast cell degranulation,reduce markedly the peripheral blood T lymphocyte in rabbits,and significantly decrease the number of antibody producing cells in mice.Conclusion:Under our experimental condition,the HBO treatment has shown to have prevented the occurance or alleviate the type Ⅰ allergic reaction in test animals;meanwhile,the cellular immune function as well as body fluid immune function were inhibited remarkbly.