高压氧对实验性腹膜粘连的防治作用(论著)

Prophylactic and therapeutic effects of hyperbaric oxygen on experimental peritoneal adhesion in rats

目的：探讨高压氧（ＨＢＯ）对实验性腹膜粘连的防治作用。方法：３６只Ｗｉｓｔａｒ大鼠采用创伤法复制实验性腹膜粘连动物模型，随机分为ＨＢＯ－Ａ组、ＨＢＯ－Ｂ组、ＨＢＯ－Ｃ组和对照组。ＨＢＯ－Ａ组和ＨＢＯ－Ｂ组于创伤后立即行ＨＢＯ治疗，分别治疗１０天和５天。ＨＢＯ－Ｃ组推迟５天才治疗，只治疗５天。创伤后１０天解剖所有大鼠，观察局部肠管色泽，并按腹膜粘连程度按级评分。结果：ＨＢＯ－Ａ组和ＨＢＯ－Ｂ组的腹膜粘连积分分别为１．２５±０．８９和１．６３±０．９２，显著低于对照组３．０８±０．７９（Ｐ＜０．０１），而ＨＢＯ－Ｃ组的腹膜粘连积分为２．８８±０．８３，与对照组相比无统计学差异（Ｐ＞０．０５）。结论：术后及时行ＨＢＯ治疗能防治实验性腹膜粘连。

Aim:To investigate the prophylactic and therapeutic effects of hyperbaric oxygen(HBO)on peritoneal adhesion in rats.Methods:36 Wistar rats with small intestine trauma induced by operation(peritoneal adhesion animal model )were randomly divided into four groups,namely the HBO A group,HBO B group,HBO C group and the control group.The rats in HBO A group and HBO B group were given HBO treatment once a day right after the operation for ten days and five days respectively;while the rats in HBO C group were given HBO treatment 5 days after the operation for five days.Results:The scores of peritoneal adhesion were not different obviously between HBO A group(1 25±0 89)and HBO B group(1.63±0.92),but the scores of both groups were significantly lower than that of the control group(3.08±0.79)and HBO C group(2.88±0.83),and there was no significant difference between the latter two groups.Conclusion:Prompt HBO treatment after the operation could prevent and treat the peritoneal adhesion as was shown in this experiment.