AMI患者hs-CRP水平及外周血淋巴细胞计数与心功能的相关性

Correlation of hs-CRP and Peripheral blood lymphocyte count with cardiac function in patients with acute myocardial infarction

目的分析联合应用hs-CRP与外周血淋巴细胞计数两个指标在急性心肌梗死(AMI)发作期间改变与心功能的相互关系,以探讨与AMI预后的相关性。方法测定健康志愿者81例(对照组)和急性心肌梗死患者86例的血清hs-CRP浓度及外周血淋巴细胞计数,同时以彩色多普勒超声检测并计算左室射血分数(LVEF)及左室后壁收缩期增厚率(△T%)。结果AMI Ⅰ组、Ⅱ组、Ⅲ组和Ⅳ组中血清hs-CRP水平明显高于对照组,并随心功能Killip分级的严重程度增加而升高,而外周血淋巴细胞计数则相反,两组比较差异有统计学意义(P<0.001);血清hs-CRP水平与心功能Killip分级呈负相关(r=-0.38,P<0.01),外周血淋巴细胞计数水平与心功能Killip分级呈正相关(r=0.97,P<0.01)。结论急性心肌梗死患者血清hs-CRP水平明显升高,与心功能Killip分级呈负相关,而外周血淋巴细胞计数水平明显降低,与心功能Killip分级呈正相关。

Objective To examine the correlation of the high sensitive - CRP （ he - CRP） levels and pe- ripheral blood lymphocyte count with cardiac function. Methods The serum levels of hs - CRP and peripheral blood lymphocyte count were detected in 81 healthy adults and 86 patients with AMI. The data of remodeling and cardiac function, such as left ventricular ejection fraction （LVEF） and left ventriadar posterior wail thickness growing rate at systole （ △ T% ）, were measured by echocardiography in all persons. Results Compared with control group, AMI patients had higher serum levels of hs - CRP （P 〈0.01 ）. The higher the upgrading of Killip class, the higher the levels of hs -CRP and the lower the peripheral blood lymphocyte count （P 〈0. 01 ）. The levels of hs - CRP were negative corelation with Killip class （ r = - 0. 38 ,P 〈 0.01 ）, but peripheral blood lymphocyte count were positive （r = 0. 97, P 〈 0.01 ）. Conclusion The levels of serum hs - CRP significantly increased in the AMI pa- tients. Th elevels of hs - CRP are negative correlation with Killip class, hut peripheral blood lymphocyte count were positive.