危重症患儿侵袭性肺部真菌感染的早期干预

Early Intervention of Invasive Pulmonary Fungal Infections of Serious Pneumonia in Children

目的探讨拟诊危重症患儿侵袭性肺部真菌感染的早期抗真菌治疗疗效。方法采用前瞻性研究方法,以我科危重症患儿中拟诊侵袭性肺部真菌感染为治疗组,临床诊断侵袭性肺部真菌感染为对照组,治疗组在拟诊真菌感染时即应用抗真菌药物,对照组在临床诊断时应用抗真菌药,比较两组患儿临床疗效。结果治疗组较对照组在退热时间、气促、咳嗽明显缓解时间、肺部阳性体征消失时间及血气恢复、肺部病变吸收时间、病原菌清除时间、住院时间等方面明显缩短,预后较好,差异有统计学意义(P<0.05)。结论危重症患儿侵袭性肺部真菌感染的早期抗真菌治疗疗效较好,值得临床推广使用。

Objective To investigate the clinical therapeutic effect of invasive pulmonary fungal infections of serious pneumonia in children. Methods Using prospective studies, the patients in control group （n = 28） were received conventional therapy and antifungal agent after clinical diagnosis IPFI, while the patients in treatment group （n = 37） were received conventional therapy, allied therapeutics with antifungal agent after pseudo - diagnosis IPFI, and the clinical therapeutic effects were compared between the two groups. Results The treatment group had shorter time than that of the control group in those such as pyretolysis, relief of short breath and cough, the extinction time of rale, recovery of blood gas, absorption of affection in sternum, elimination of pathogenic bacteria, and the days of hospital stay. The treatment group showed better prognosis than that of the control group, and the difference was statistically significant （P〈 0. 05）. Conclusions The clinical therapy is effective that we adopt the early treatment of invasive pulmonary fungal infections of serious pneumonia in children, and the therapy plan is worth using widely.