胸腔热灌洗联合榄香烯乳治疗恶性胸腔积液疗效观察

Hyperthermo-chemotherapy of intrapleural perfusion combined with elemene for malignant pleural effusion

目的观察胸腔热灌洗联合榄香烯乳治疗恶性胸腔积液的疗效,探讨治疗恶性胸腔积液的有效方法。方法59例恶性胸腔积液病人随机分成2组,治疗组30例采用胸腔内置管热灌洗联合榄香烯乳治疗;对照组29例采用顺铂(DDP)100mg/m2胸腔内注入。对2组病人的治疗效果进行评估。结果治疗组30例中显效23例,有效6例,无效1例,总有效率96.7%;对照组29例中显效9例,有效8例,无效12例,总有效率58.6%。2组总有效率比较差异有统计学意义(P<0.05)。治疗组1年生存数与死亡数分别为18例、12例,对照组分别为9例、20例。2组1年生存率分别为60.0%、31.0%,差异有统计学意义(P<0.05)。2组均无严重不良反应。结论胸腔内热灌洗联合榄香烯乳治疗恶性胸腔积液有效率高,毒副作用小,病人易于耐受。

Objective To evaluate the efficacy of hyperthermo-chemotherapy of intrapleural perfusion combined with elemene in treatment of malignant pleural effusion in order to find a new method to treat malignant pleural effusion. Methods A total of 59 patients with malignant pleural effusion were randomly divided into two groups. Thirty cases were treated with hyperthermo-chemotherapy of intrapleural perfusion combined with elemene as treated group ;twenty-nine cases were treated with intrapleual perfusion（ DDP 100 mg/m^2 ） as control group. The treatment effect,median survival time and toxicities were assessed four weeks after treatment. Results The median survival time was higher significantly in treatment group than that in control group（ P 〈 0. 05 ）. The effective rate was 96. 7 % in treatment group and 58. 6% in control group, and there was significant difference between two groups （ P 〈 0. 05 ）. The one year survival rate was higher in treatment group than that in control group （60. 0% vs 31.0% ,P 〈 0：05 ）. There were no severe adverse effects in two groups. Conclusions Hyperthermo-chemotherapy of intra- pleural perfusion combined with elemene is an effective and well tolerated method with slight side effect for the malignant pleural effusion.