平邑县1999—2008年新生儿疾病筛查结果分析

Analysis on Results of Neonatal Illness Screening In 1999—2008 Pingyi County

目的了解两种疾病的发病率,探讨新生儿疾病筛查(简称新筛)工作中存在的问题和对策。方法选择1999年9月—2008年9月在平邑县各助产机构内分娩的活产新生儿为筛查对象,于出生后72小时,充分哺乳后采足跟血,10日内送临沂市新生儿疾病筛查中心检测促甲状腺素(TSH)和苯丙氨酸(Phe)以筛查先天性甲状腺功能减低症(CH)和苯丙酮尿症(PKU)。结果9年共出生81721人,参与筛查79145人,筛查率为98.05%,血片合格率为99.15%,复采召回率达99.65%。检出CH患儿32例,发病率为4.04/万,PKU患儿13例,发病率为1.64/万。结论平邑县两种疾病的发病率较全国平均水平(CH:3.32/万,PKU:0.90/万,血片合格率和复采召回率有待提高;明确各级人员职责,做好宣传告知工作,提高群众和家长对新筛意义的认识,是进一步提高筛查率,降低患儿致残率,提高出生人口素质的关键。

OBJECTIVE Understand the two diseases morbidity, explore new sieve existing problem and countermeasure. METHODS The September 1999—September 2008 Pingyi County in the institution of childbirth midwifery live-birth newborn screening, born in for 72 hours after after lactation, full of blood, 10 days to send Linyi Neonatal Illness Screening Test Center for thyroid-stimulating hormone （TSH） and phenylalanine（Phe） to screening congenital thyroid function and reduce benzene acetone urine. RESULTS The total was born 81721 in nine years, 79 145 people participate in screening, the screening rate for 98.05%,99.15% for blood qualified, mining the recall rate reaches 99.65%. Detected CH patients 32 incidence（4.04‰）, PKU children in 13 patients, 1.64‰ morbidity. CONCLUSION Two of the disease than the national average level （CH：3.32‰, PKU ：0.90‰） high blood, qualified and mining, recalling rate to improve staff at all levels duty, publicity, improve the masses inform parents and understanding of the significance of the new sieve, further improve the screening rate, reduce children morbidity, improve the quality of the population was born.