慢性肝病患者血清Ⅳ型胶原降解酶活性的研究

Serum Type Ⅳ Collagen-Degrading Enzyme Activity in Patients with Chronic Liver Disease

为了解基质降解在慢性肝病中的作用,对慢性肝炎、肝硬化患者的血清Ⅳ型胶原降解酶活性进行了研究.结果表明:慢性肝炎、肝硬化患者的血清Ⅳ型胶原降解酶活性均显著高于正常对照组;慢性肝炎患者酶活性较肝硬化患者亦显著为高.血清Ⅳ型胶原降解酶活性与PⅢP、Laminin间均呈显著负相关.上述结果提示.Ⅳ型胶原降解酶可能参与了慢性肝病的病理发生;随着慢性肝病的进展,酶活性逐渐下降.

In order to investigate the ettect ot matrix degradation in chronic liver disease, serum type Ⅳ collagen-degrading enzyme activityin patients with chronic hepatitis and liver cirrhosis were studied. Results showed that serum type Ⅳ collagen-degrading enzyme activity in patients with chronic hepatitis and liver cirrhosis were much higher than that in normal control. The enzyme activity in patients with chronic hepatitis was still significantly higher than that in patients with liver cirrhosis Serum type Ⅳ collagen-degrading enzyme activity was significantly and inversely correlated with serum PⅢ P and larnimn concentration. These indicates that type Ⅳ collagen-degrading enzyme may participate in pathogenesis of liver fibrosis and cirrhosis and the enzyme activity decreases gradully in the progression of chronic liver disease