抽动障碍患儿血清脑源性神经营养因子及微量元素锌水平检测及临床意义

Derived neurotrophic factor and zinc in tic disorders children and its clinical significance

目的:检测抽动障碍(TD)患儿血清中脑源性神经营养因子及微量元素锌水平,研究其临床意义。方法:按照中国精神障碍分类与诊断标准第3版中的抽动障碍分类与诊断标准选取30名患儿,选取15名年龄、性别类同的健康儿童作为对照组。应用酶联夹心免疫吸附法测定受试者血清BDNF的水平,原子吸收法测定血锌水平,与健康儿童进行比较。结果:与对照组相比,患儿血清BDNF的水平升高,差异有统计学意义(P<0.05);两者血锌水平相当,无统计学意义(P>0.05)。结论:BDNF参与抽动障碍的发病,外源性BDNF的介入可能成为干预、防治TD的有效方法。抽动障碍患儿血锌水平无明显变化。

Objective： To investigate the levels of brain derived neurotrophic factor（BDNF）, zinc and evaluate their clinical significance in children with tic disorders （TD）. Methods： Thirty children with TD and thirty age and sexy matched healthy controls were enrolled in this study. Serum levels of BDNF were detected by enzyme linked immunosorbent assay. Levels of zinc were measured by Atomic Absorption Spectrophotometry （AAS）. Results： The mean concentration of serum BDNF in TD group was significantly higher （P〈0.05） than that of the control group. The mean concentration of zinc in two groups were not different. Conclusion： Serum BDNF lev- els in children with TD are higher than that in normal children. BDNF is connected with the happening of TD, BDNF may become effective method to prevent and cure TD. Zinc levels in two groups are not different.