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HLA-Cw与银屑病相关性的研究 被引量：3

The study of the Association between HLA-Cw and Psoriasis
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摘要 银屑病是一种多基因疾病,其原因尚未完全清楚。迄今为止,在OMIM中收录了七个银屑病易感基因位点,染色体6p上的PSORS1是当前银屑病的研究热点。PSORS1(银屑病易感基因1)对银屑病来说是一个主要的易感位点。目前将银屑病分为Ⅰ型和Ⅱ型,其中位于PSORS1上的HLA-Cw认为与Ⅰ型银屑病的联系最强。在以往的文献报道认为HLA-Cw与汉族银屑病患者的关系最为密切,但在新疆维吾尔族人中尚未发现这一相关性。 Psoriasis is a Multi-gene disease, the reason of which is not clear. At present, there have 7 psoriasis predisposing genes locus in OMIM, the PSORS 1 on chromosomes 6p is the hot spot. PSORS 1 （psoriasis susceptibility gene 1） is a major susceptibility locus for psoriasis. Now psoriasis is derided into two type by the reseachers, type I and type . HLA-Cw of PSORS1 is considered to have the strongest relation with psoriasis type I in previous literature reports. Many reports show that HLA-Cw have the strongest relation with han patients with psoriasis in China, but this result has not been proved in Xi Jiang Uighurs.
作者 朱明明 普雄明 吴卫东
机构地区 石河子大学医学院 新疆维吾尔自治区人民医院附属皮肤性病科
出处 《现代生物医学进展》 CAS 2009年第17期3345-3347,共3页 Progress in Modern Biomedicine
基金 国家自然基金项目资助(30640056)
关键词 银屑病 人类白细胞抗原 Psorisis Human leukocyte antigen
分类号 R758.63 [医药卫生—皮肤病学与性病学]
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参考文献27

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二级参考文献3

共引文献4

同被引文献37

  • 1马红京,肖露露,郭坤元.HLA-Cw研究进展[J].中国实验血液学杂志,2004,12(5):699-703. 被引量：4
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  • 8Jiao YL, Ma CY, Wang LC, et al. Polymorphisms of KIRs gene and HLA-C alleles in patients with ankylosing spondylitis: possible association with susceptibility to the disease [ J ]. J Clin Immunol, 2008,28 (4) :343-349.
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现代生物医学进展
2009年 第17期

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