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DNA甲基化的研究进展 被引量：7

Progress in the research on DNA methylation
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摘要 甲基化修饰是脊椎动物DNA唯一的自然修饰方式,动物基因组甲基化与基因表达密切相关。DNA甲基化通过与反式作用因子相互作用或通过改变染色质结构而影响表达,在细胞分化、发育、X染色体失活、基因组印记及肿瘤发生发展中起重要作用。 The methylation beautification is the vertebrate DNA only nature beautification way, the animal genome team methy- lation and the gene expression close related. The DNA methylation through affects with the trans-acting factor interaction or through the change chromatin structure expresses, and play an important role in the cell deferention, development, X chromosome deactivation, the genome team mark and the tumor.
作者 谢松松 王宝峰 周宗瑶
机构地区 新疆石河子大学医学院
出处 《现代生物医学进展》 CAS 2009年第17期3368-3370,共3页 Progress in Modern Biomedicine
关键词 DNA 甲基化 研究 DNA Methylation Research
分类号 Q75 [生物学—分子生物学] Q78 [生物学—分子生物学]
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参考文献21

  • 1Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality [J]. Cell 1992;69: 915-926.
  • 2Bestor T, Laudano A, Mattaliano R, et al. Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells[J]. Mol Biol, 1988, 203(4): 971-983.
  • 3Wyatt GR. Occurence of 5-methyl-cytosine in nuceic acids[J]. Nature, 1950, 166:237-238.
  • 4陈瑞琳 蔺淑梅 陈天艳等.DNA甲基化及其影响因素.国际流行病学传染病学杂志,2007,34(4):252-2552.
  • 5Attwood JT, Yung RL, Richardson BC. DNA methylation and the regulation ofgene transcription. [J]. Cell Mol Life Sci, 2002,59 (2) : 241-257.
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  • 7孔祥东,王军,张思仲.DNA甲基化与发育调节[J].生物学通报,2000,35(8):19-20. 被引量：2
  • 8Schmiemann V, Bocking A, Kazimirek M, et al. Methylation assay for the diagnosis of lung cancer on bronchial aspirates:a cohort study[J]. Clin Cancer Res, 2005, 11 (21): 7728-7734.
  • 9Leung W K, To K F, Man E P, et al. Detection of epigenetic changes in fecal DNA as a molecular screening test forcolorcctal cancer: a feasibility study[J]. Clin Chem, 2004, 50(11): 2179-2182.
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二级参考文献24

  • 1[1]Hsu DW,Lin MJ,Lee TL et al.Two major forms of DNA(cytosine-5)methyltransferase in human somatic tissues.Proc Natl Acad Sci USA.1999,17,96(17):9751-6.
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  • 7Gaudet F, Rideout WM 3rd, Meissner A, et al. Dnmtl expression in pre- and postimplantation embryogenesis and the maintenance of lAP silencing. Mol Cel Biol, 2004, 24 : 1640-1648.
  • 8Meissner A, Gnirke A, Bell GW, et al. Reduce depresentation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res,2005 ,3 :5868-5877.
  • 9Kim M, Trinh BN, Long TI , et al. Dnmtl deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells. Nucleic Acids Res, 2004, 32:5742-5749.
  • 10Reik W, Dean W, Walter J. Epigenetic reprogramming in mammalian development. Science,2001,293 : 1089-1093.

共引文献6

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二级引证文献12

现代生物医学进展
2009年 第17期

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