诱导MSCs向成骨细胞分化相关因素研究现状

Research Status of Related Factors on Inducing MSCs to Differentiate into Osteoblasts

骨髓间充质干细胞(mesenchymal stem cells,MSCs)是干细胞家族的重要成员,是一类具有自我增殖和多项分化潜能的多能干细胞。MSCs定向分化为成骨细胞将可能为包括骨缺损、骨折不愈合、股骨头坏死等多种骨科难治性疾病的治疗带来一场革新。本文主要介绍了化学因素、生物因素、他汀类药物、物理因素、转基因技术以及中医药等相关因素诱导MSCs向成骨细胞分化的研究现状。

Mesenchymal stem cells are an important member of stem cell family and a kind of multipotent stem cells which have self-proliferative and multilineage differentiation potentiality. MSCs directed differentiated into osteoblasts may bring about a reform on the treatment of a variety of refractory orthopedics disease, such as bone defect, nonunion and osteonecrosis, et al. This paper describes the research status of related factors （including chemical factors, biological factors, statins, physical factors, transgenic technology and traditional Chinese medicine）on inducing MSCs differentiate into osteoblasts.