摘要
目的：建立肝纤维化血清学诊断谱，并探讨其在肝纤维化诊断与疗效考核中的意义。方法：用四氯化碳诱导大鼠产生肝纤维化动物模型，动态测定多种血清学指标。经筛选，确定血清有机膦酸酯酶（ＰＥ）、一氧化氮（ＮＯ）、Ⅲ型前胶原（ＰＣⅢ）与透明质酸（ＨＡ）四种指标为联合检测谱。在此基础上，测定了１７１例急、慢性肝病患者这四种指标的变化。结果：随着肝纤维化程度的加深，这些血清学指标也相应逐渐升高，四种指标联合检测的敏感性为９６％～９８％，特异性为８９％。而在抗肝纤维化治疗后，这一诊断谱也相应降低。
Objective:To establish a serum diagnostic method for hepatic fibrosis and to explore its value in the diagnosis and curative effect assessment of hepatic fibrosis.Methods:Liver fibrosis was induced in rats by injection of carbon tetrachloride.Serum PCIII,HA,PE and NO were measured dynamically.The levels of above serum markers were also detected in 171 cases of patients with acute or chronic liver diseases.Results:During developing process of liver fibrosis,serum levels of the above four markers were increased gradually.The sensibility for liver fibrosis was 96%～98%,and its specificity was 89%.After treating with tetrandrine or colchicin,these markers were decreased correspondently.Conclusion:The serum diagnostic procedure may be used as an index in the diagnosis and curative effect assessment of liver fibrosis.
出处
《滨州医学院学报》
1998年第5期420-423,共4页
Journal of Binzhou Medical University
关键词
肝纤维化
血清学标志物
联合检测谱
诊断
hepatic fibrosis
combined measurements
diagnosis
serology
curative effect assessment
