损毁伏隔核多巴胺神经末梢对二氢埃托啡偏爱效应的影响

INFLUENCE OF 6 HYDROXYDOPAMINE LESIONS OF NUCLEUS ACCUMBENS ON THE PLACE PREFERENCE INDUCED BY DIHYDROETORPHINE

目的：研究伏隔核（ＮＡｃ）中多巴胺（ＤＡ）神经末梢在二氢埃托啡（ＤＨＥ）精神依赖性中的作用。方法：采用条件性位置偏爱实验反映ＤＨＥ的精神依赖性。结果：ＤＨＥ（０．５μｇ·ｋｇ－１，ｓｃ）单独给药产生显著的位置偏爱效应。用６－羟多巴胺（６－ＯＨＤＡ）选择性损毁ＮＡｃ的ＤＡ能神经元末梢后，大鼠则不能对ＤＨＥ形成偏爱效应。

Objective :To study the influence of 6 hydroxydopamine(6 OHDA)lesions of the nucleus accumbens(NAc) on the dihydroetorphine(DHE)rewarding effect. Methods :The conditioned place preference paradigm was used to evaluate the rewarding effect of DHE. Results :DHE(0 5μg·kg -1 ,sc)produced significant place preference to drug paired side.Bilateral 6 OHDA lesions of dopamine(DA)terminals of the NAc abolished the place preference produced by systemically administered DHE.Conclusion:The intact DA neurons in NAc are important for the establishment of DHE induced place preference.