摘要
目的:探讨不同种类的妇科肿瘤患者血清IL-6、TNF-α和IFN-α的表达。方法:采用双抗体夹心ELISA法和放射免疫法。结果:不同种类的妇科恶性肿瘤患者血清IL-6、TNF-α和IFN-α水平均明显高于不同种类的妇科良性肿瘤(P<0.01,P<0.05)。4种妇科恶性肿瘤血清IL-6的表达依次为:卵巢恶性肿瘤、恶性滋养叶细胞肿瘤、子宫内膜癌、宫颈癌,其均值分别为786.89pg/ml、419.67pg/ml、186.80pg/ml、149.67pg/ml。血清TNF-α的表达依次为:宫颈癌、卵巢恶性肿瘤、恶性滋养叶细胞肿瘤、子宫内膜癌,其均值分别为850pg/ml,842.86pg/ml、725pg/ml、700pg/ml。血清IFN-α的表达依次为:宫颈癌、卵巢恶性肿瘤、子宫内膜癌、恶性滋养叶细胞肿瘤。其均值分别为:243.33pg/ml、237.89pg/ml、201.40pg/ml、198.78pg/ml。结论:3种细胞因子的测定对恶性肿瘤的病情估计和预后判断有重要价值。
Objective:To study the serum levels of interleukin 6(IL 6),tumor necrosis factor alpha(TNF α) and interferon alpha(IFN α) in gynecological tumor patients.Methods:Enzyme linked immunosorbent assay(ELISA) and radioimmunoassay were used to dertermine the levels of cytokines in serum.Results:Serum levels of IL 6,TNF α and IFN α in patients with gynecological malignant tumors were significantly higher than those in patients with gynecological benign tumors ( P<0 01,P<0 05,P<0 05 ).In gynecological malignant tumors serum IL 6 expression was ovarian malignant tumor (786 89 pg/ml),gestational trophoblastic tumor (419 67 pg/ml),carcinoma of endometrium (186 80pg/ml),carcinoma of cervix uteri(149 67 pg/ml).Serum TNF α expression was carcinoma of cervix uteri (850 pg/ml),ovarian malignant tumor (842 86 pg/ml),gestational trophoblastic tumor (725 pg/ml),carcinoma of endometrium(700 pg/ml).Serum IFN α expression was carcinoma of cervix uferi (243 33 pg/ml),ovarian malignant tumor (237 89 pg/ml),carcinoma of endometrium(201 40 pg/ml),gestational trophoblastic tumor(198 78 pg/ml).Conclusion:By using three cytokines,the patients conditions can be detected,the prognosis of gynecological malignant tumors can be estimated.
出处
《滨州医学院学报》
1998年第6期543-545,共3页
Journal of Binzhou Medical University
关键词
妇科肿瘤
IL-6
干扰素
肿瘤坏死因子
gynecological tumor
interleukin 6
interferon alpha
tumor necrosis factor alpha