MG_7、MGd_1单克隆抗体在卵巢粘液上皮肿瘤中的表达及对患者预后的意义

Expressions of monoclonal antibodies MG 7,MGd 1 in ovarian mucinous epithelial tumous and patient's prognostic significance.

目的：探讨抗胃癌单克隆抗体ＭＧ７、ＭＧｄ１在卵巢粘液上皮肿瘤（ＯＭＥＴ）组织中的表达与临床资料和患者预后的关系。方法：应用免疫组化ＳＰ法检测９３份ＯＭＥＴ组织中ＭＧ７、ＭＧｄ１的表达，并对１４ａ经手术切除、病理学检查证实的ＯＭＥＴ患者的临床资料进行患者预后分析。结果：ＭＧ７、ＭＧｄ１定位于ＯＭＥＴ细胞膜及附近的胞浆，ＭＧ７在良性、交界性、恶性组表达率分别为０、８０．６５％、１００％，ＭＧｄ１分别为２６．４７％、９６．７７％、１００％。３组间差异有显著性（Ｐ＜０．０５）。恶性组ＭＧ７过度表达率比ＭＧｄ１者高１４．２８％。将本组ＯＭＥＴ的临床资料、ＭＧ７和ＭＧｄ１染色结果分别经ＣＯＸ风险模型分析，发现期别、肿瘤直径和ＭＧ７染色指标是影响患者预后的主要因素。ＯＭＥＴＭＧ７表达（—）、（＋）、（）和（）组的患者５ａ生存率分别为１００％、７２．３７％、２７．９％和１３．１３％，ＭＧｄ１分别为（—）１００％、（＋）７５．０５％、（）３１．４７％、（）０．００％。结论：卵巢癌与胃癌组织间存在共同抗原性，具有同源性。ＭＧ７、ＭＧｄ１对ＯＭＥＴ的诊断有一定的特异性和敏感性，与临床病理分级、分类及预后有关，为ＯＭＥＴ的?

Objective:To study the expressions of antigastric cancer monoclonal antibodies MG 7 and MGd 1 in ovarian mucinous epithelial tumors(OMET) and the relationship with clinical materials and patient's prognosis. Methods:93 specimens of OMET were collected to determine the expressions of monoclonal antibodies MG 7,MGd 1 by using immunohistochemical strepavidin peroxidase conjugated assay(SPCA), the correlation between clinical materials of the patients of 14 years after histopathologic identification and patient's prognosis of 93 cases had been analysed.Results:Monoclonal antibodies MG 7,MGd 1 localized on cytomembranes and their cytoplasma.Expressions of MG 7 in the specimens of benign,borderline,malignant OMET were 0、80.65%、100%.Those of MGd 1 were 26.47 %、96.77%、100% respectively.The differences among three groups were significant( P <0.05).In malignant group,overexpression of MG 7 was 14.28% higher than that of MGd 1.Clinical materials,expression of MG 7 and MGd 1 had been analysed by using COX harzards model and the clinical stage,tumor diameter,and staining of MG 7 were the main inflluence factors of patient's prognosis.MG 7 and MGd 1 expression degrees related with patient's 5 a survival rate.MGD 7 were (-)100%,(+)27.91%,()72.37%,()13.13%,MGD 1 were (-)100%,(+)75.05%,()31.47%,()0,sespectively.Conclusions:The results of this research show that gastric cancer and OMET tissues exist related antigen.There are higher sensitivity and specificity of MG 7 and MGd 1 expression in OMET,which is obviously related to patient's prognoses.It helps the classification and gradation of clinical pathology and provides a new means for early differential diagnosis of OMET.