癫痫患者血浆及脑脊液中一氧化氮含量的变化与临床意义

A study on palsma and csf NO concentration in epileptic patients and its clinical significance

采用高效液相色谱法对37例正常对照病人和58例癫痫病人血浆及脑脊液中一氧化氮(NO)含量进行检测。结果显示:癫痫患者血浆及脑脊液中NO含量明显升高,与对照组相比有显著性差异,P均<0.01,且近期有癫痫发作者其血浆及CSF中NO含量较无发作者升高更明显,但与病程、年龄、性别及发作类型、用否抗痫药物无关。提示:NO参与了癫痫发病的病理生理过程。

By high performance liquid chromatography (HPLC) method the NO concentration in plasma and CSF of 37 control subjects and 58 epileptic patients was measured. The result showed that the NO concentrations in palsma and CSF were significantly higher in epileptic patients thean that in the control group (P<0. 01). The plasma and CSF NO concentration in patients during the period of epileptic attack were significantly higher than those in the attack - free periods (P < 0. 01). There were no significant correlations between the NO concentration and the age sex. course, type of epileptic or the antiepileptic drugs. The result suggest that the NO play a role in the deveeopment of epilezy.