摘要
目的：建立图像分析对微丸形态学的评价方法，优化双氯芬酸钠微丸挤出滚圆制备工艺。方法：以微丸粒径和圆整度参数为响应值，3^2析因设计滚圆转速、滚圆时间对微丸形态的影响，研究并优化工艺条件。结果：滚圆转速提高所得微丸粒径减小，圆整度提高。滚圆时间对粒径无显著影响。在滚圆转速22Hz，滚圆时间8min的最优工艺条件下可以制得粒径在800～850μm，eR〉0．48的微丸。结论：应用图像分析法直观、简捷地优化了挤出滚圆工艺.
Objective： The method of image analysis was established as the means of evaluating and optimizing the characteristic of some pellets prepared in a extrusion-spheronization process. Methods： A 3^2 full factorial design study has been employed to investigate the effect of two variables （ spheroniza- tion rate and spheronization time） on size, size distribution and two shape parameters （elongation and eR） of pellets prepared in extrusion-spheronization process. Results： Smaller pellets were obtained when higher spheronization rate was used, and the shape was enhanced. The influence of spheronization time was not significant. The pellets with size of 800 - 850 μm, eR 〉 0.48 were obtained at optimum point, at rate 22Hz and time 8 min. Conclusions： The process of extrusion-spheronization was optimized directly and conveniently by image analysis.
出处
《药学与临床研究》
2009年第5期382-385,共4页
Pharmaceutical and Clinical Research
关键词
微丸
挤出滚圆
图像分析
粒径分布
圆整度
Pellet
Extrusion-spheronization
Imagine analysis
Size distribution
Shape parameters
