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非诺贝特胶囊致横纹肌溶解1例

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摘要 1例78岁女性患者,因血脂增高口服非诺贝特胶囊200 mg、qn。服药14 d后出现双下肢胀痛难忍,无力,行走困难。检查心肌酶谱:门冬氨酸氨基转移酶191 IU.L-1,乳酸脱氢酶1209 IU.L-1,肌酸激酶5200IU.L-1,肌酸激酶同工酶>300 IU.L-1;肾功能:尿素12.10 mmol.L-1,肌酐169μmo.lL-1。遂停用所有可疑药物,给予保肝、保肾、水化、碱化疗法;4 d后患者肌肉疼痛、乏力症状明显减轻,复查心肌酶谱:门冬氨酸氨基转移酶147 IU.L-1,乳酸脱氢酶1020 IU.L-1,乳酸肌酶1380 IU.L-1,肌酸激酶同工酶83 IU.L-1;肾功能:尿素8.0 mmol.L-1,肌酐146μmo.lL-1;各项指标均有好转。
出处 《药学与临床研究》 2009年第5期414-415,共2页 Pharmaceutical and Clinical Research
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