神经系统肿瘤恶性程度与其基因产物表达的不稳定性相关

Gene product expression associated with malignancy of neural neoplasia

用免疫组化法检测了１０例中枢神经系统肿瘤和１０例末梢神经系统肿瘤细胞中ＰＣＮＡ、ｂｃｌ－２、Ｆａｓ、ＢＭ－１、Ｒｂ和ｐ５３基因产物的表达。ＰＣＮＡ、ｂｃ１－２、Ｆａｓ、ＢＭ－１、Ｒｂ和ｐ５３在中枢神经系统肿瘤中分别有７、１、４、０、２、３例阳性；而在末梢神经系统肿瘤中则各有４、５、１０、０、５、０例阳性。在两者之间存在基因产物表达上的差异。但无论在中枢或末梢神经系统肿瘤中ＰＣＮＡ和ｂｃ１－２同时表达的病例明显预后不良。

Tumor cells in 10 central neural tumors and 10 peripheral neural tumors were examined immunohistologically by ABC method using specific antibodies to PCNA,bcl-2,Fas,BM-1,Rb and p53.Tumor cells gave positive reactions in 7,1,4,0,2and 3 cases in central neural tumors and in 4,5,10,0,5 and 0 cases in peripheral neural tumors in the test with PCNA,bcl-2 Fas BM-1,Rb and p53,respectively.Tumors positive for both PCNA and bcl-2 had poor outcome.The expression of certain gene products associated with growth regulation may be useful for estimating the malignancy of neural tumors.