绝经妇女的血脂变化与心血管疾病的探讨

The investigation of plasma lipoprotein change and cardiovascular diseases in menopause women

目的绝经妇女的血脂变化与心血管疾病发生相关性及预防措施。方法以绝经后健康妇女139例为观察对象,以生活水平,生活习惯,饮食习惯相似的125例绝经前健康妇女作为对照,以同一份血清用全自动生化分析仪做总胆固醇(CH),甘油三酯(TG)、低密度脂蛋白血胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(APOA1)、脂蛋a[Lp(a)]6项检查。结果两组CH、TG、HDL-C、LDL-C、APOA1、LP(a)6项指标比较有显著差异。结论绝经后妇女血清CH、TG、HDL-C、LDL-C、LP(a)较绝经前明显升高,而HDL-C、APOA1明显下降;血脂代谢紊乱是绝经后雌激素水平下降所致。医生应该认识到激素替代治疗仍旧是绝经妇女预防疾病,保持生活质量的主要手段。

Objective To investigate the relationships between the plasma lipoprotein change and the cardiovascular diseases and the preventive measures in menopause women. Methods 139 healthy women in menopause with the parallel control of 125 healthy women who are not menopausal and have the similar life level, the similar life habits and the similar dietary habits are included. CH, TG, LDL-C, HDL-C, APOA1 and a[ Lp （a） ] are detected by using biochemistryassay with the same blood serum. Results The values of CH,TG, LDL- C, HDL-C, APOA1 and a[ Lp （a） ] are great different in two groups. Conclusion Compared with the controls, we find that CH ,TG, LDL-C, and a [ Lp （a） ] are apparently higher but HDL-Cand APOA1 are apparently lower in the menopause women. We also find that the disorder of the plasma lipoorotein supersession induced by the level of serum lipoid in menopause women. The main means that prevent the menopausal women from disease and improve their life quality are still hormone replacement therapy.