高血压病淋巴细胞β_2受体的变化以及卡托普利对该受体的影响

Alterations of Lymphocytes β 2 adrenergic Receptors and theEffect of Captopril on the Receptors in Essential Hypertension

目的研究高血压病不同期淋巴细胞β２受体的改变以及卡托普利对该受体的影响。方法应用放射性配基结合法（Ｈ－双氢阿普洛尔，Ｈ－ＤＨＡ）测定高血压病患者外周血淋巴细胞β２受体密度以及卡托普利对左心室肥厚患者该受体的作用。结果高血压病左心室肥厚患者β２受体密度比正常对照组明显增加；心衰患者受体密度随心功能恶化呈下降趋势；左室肥厚患者应用卡托普利后受体表现为下调。结论高血压不同期的淋巴细胞β２受体变化各异；卡托普利对受体的作用与心室肥厚逆转、平均动脉压下降以及心脏负荷降低等因素有关。

Aim\ To investigate the alterations of Lymphocytes β adrenergic receptors (β 2 AR) and the effect of captopril on the receptors in essential hypertension.\ Methods\ the density of lymphocytes β 2 AR was measured with radio Ligand binding ( 3H Dihydroalprenolol, 3H DHA) method and the effect of captopril on the receptors was determined.\ Results\ The density of lymphocytes β 2 AR was markedly increased in patients with left ventricular hypertrophy (LVH) and decreased in patients with heart failure (CHF).\ After treatment with captopril for sixteen weeks, the increased density of β 2 AR had decreased in the patients with LVH.\ Conclusion\ The changes of lymphocytes β 2 AR were different according to the degrees of Hypertension;Captopril could down regulate the density of Lymphocytes β 2 AR in the patients with LVH; the effect was correlated with regression of LVH ,reduced MBP and decreased cardiac loading.