用动态血压监测的方法评价塞利洛尔的降压疗效

Evaluation of the Antihypertensive Effect of Celiprolol with ABPM

目的用２４ｈ动态血压监测的方法评价塞利洛尔降压疗效及作用持续时间。方法符合入选条件的轻中度高血压病患者３２例，平均４８．６±７．８岁。服安慰剂２周后，每天服用塞利洛尔１００～３００ｍｇ共６周，治疗前后分别监测２４ｈ动态血压。结果治疗后２４ｈ、白天、夜间的ＳＢＰ和ＤＢＰ均有明显下降（Ｐ＜０．０１）；血压负荷值亦明显减小（Ｐ＜０．０１）；ＳＢＰ及ＤＢＰ谷峰比值均＞５０％。心率无明显变化（Ｐ＞０．０５）。结论：塞利洛尔的降压作用能持续２４ｈ以上，且安全有效。

Objective\ To evaluate the antihypertensive effect of celiprolol by 24h ambulatory blood pressure monitoring(ABPM). \ Methods\ According to a open, self and placebo controlled design, thirty two cases with mild to moderate hypertension aged at 48.6±7.8 years, were studied. After a 2 week period of placebo taking, patients were given celiprolol 100 mg～300 mg once daily for 6 weeks.\ Results\ After 6 weeks of celiprolol treatment, 24 h, day and night SBP and DBP showed a statistically significant reduction( P <0.01); SBP and DBP loads decreased obviously( P <0.01); T/P ratios of both SBP and DBP were larger than 50%. No changed in heart rate was found( P >0.05).\ Conclusion\ The antihypertensive effects of celiprolol could sustain over 24 h in patients with mild and moderate essential hypertension.