药学干预对基层医院抗生素使用结构的影响(英文)

Impact of pharmaceutical intervention on the rational use of antibiotics in primary hospital

根据基层医院特点,通过合理的药学干预,可以使不同种类抗生素的使用更趋合理。建立药学干预四项措施,1)对抗生素实行分级管理制度;2)逐月对各科室抗生素使用情况进行全院通报;3)启动抗生素预警制度;4)临床药师下临床加强与医师的交流沟通。对2007(干预前)、2008(干预后)两个年度呼吸内科抗生素使用情况进行对比分析。抗生素使用从集中于一类药品转向多种轮替使用,干预前与干预后抗生素的使用情况具有显著性差异(P<0.01)。合理的药学干预是抗生素合理使用的有效手段。

Evidence based pharmaceutical interventions focusing on the characteristics of antibiotics use in primary hospitals were investigated to optimize the use of antibiotics. Four pharmaceutical interventions were set up in this study： 1） different levels of antibiotic management system were developed; 2） usage of antibiotics was reported in a monthly journal for the entire hospital; 3） early antibiotics warning system was started; 4） communication between pharmacists and physicians was strengthened. Use of antibiotics in 2007 （before intervention） and 2008 （after intervention） in department of respiratory medicine was analyzed. Significant differences （P〈0.01） in antibiotics use before and after intervention were observed. Use of antibiotics was changed from focusing on one category of drugs to a rotation of a wide range of agents. Evidence based, sound pharmaceutical interventions were effective means to ensure the rational use of antibiotics.