自体骨髓干细胞移植治疗肝硬化的研究进展
被引量:4
摘要
自体骨髓于细胞移植被认为是目前最新的、非常有前景的一种治疗方法。经过多年来动物模型及临床的研究,已经证实其有效性.此方法还具有操作简单、创伤小、不存在排斥反应、并发症少、费用低等优点,给广大肝硬化患者带来了新的希望。
出处
《现代医药卫生》
2009年第20期3097-3098,共2页
Journal of Modern Medicine & Health
参考文献16
-
1Sato Y,Araki H,Kato J,et al.Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion[J].Blood,2005,106(2):756.
-
2Petersen BE,Bowen WC,Patrene KD,et al.Bone marrow as apotential source of hepatic oval cells[J].Science,1999,284(5417):1168.
-
3Okumoto K,Saito T,Hattori E,et al.Differentiation of rat bone marrow ceHs cultured on arti?cial basement membrane containing extracellular matrix into a liver cell lineage[J].Journal of Hepatology,2005,43(1):110.
-
4吴玉卓,张玉婷,毛小荣,陈红.EGF和HGF体外诱导肝硬化患者骨髓间充质干细胞向肝细胞分化的实验研究[J].第三军医大学学报,2008,30(16):1541-1544. 被引量:10
-
5Khan A.A,Parveen N,Mahaboob V.S,et al.Safety and efficacy of autologous bone marrow stem cell transplantation though hepatic artery for the treatment of chronic liver failure:a preliminary study[J].Transplantation Proceedings,2008,40(4):1140.
-
6唐力军,高毅,李浩,单毓强,姜晓丹,柳晓秋.人骨髓来源的多能成体祖细胞分离纯化及体外培养的实验研究[J].中国临床康复,2005,9(2):85-87. 被引量:8
-
7Levicar N,Pai M,Habib N.A,et al.Long-term clinical results of autologous infusion of mobilized adult bone nlarrow derived CD34+ cells in patients with chronic liver disease[J].Cell Prolif,2008,41Suppl 1:115.
-
8Haga J,Wakabayashi G,Shimazu M,et al.In Vivo Visualization and Portally Repeated Transplantation of Bone Marrow Cells in Rats with Liver Damage[J].Stem cells and development,2007,16(2):319.
-
9Liu Z.C,Chang T.M.Transdifferentiation of bioencapstdated bone marrow eels into hepatocyte-like ceils in the 90%hepatectomized rat model[J].Liver Transplantation,2006,12(4):566.
-
10Ju S,Teng G J,Lu H,et al.In Vivo MR Tracking of Mesenchymal Stem Cells in Rat Liver after Intraspleulc Tram plantation[J].Radiology,2007,245(1):206.
二级参考文献37
-
1何忠杰,方驰华,马俊勋,杨丽萍.肝细胞生长因子与表皮细胞生长因子联合诱导大鼠骨髓间充质干细胞分化为类肝细胞[J].解放军医学杂志,2006,31(5):446-449. 被引量:14
-
2Phillips P.New surgical approaches to Parkonson disease.美国医学杂志(中文版),2000,19(2):96-96.
-
3Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002; 418 (6893):41 -9.
-
4Friedenstein AJ. Precursor cells of mechanocytes. Int Rev Cytol 1976; 47:327 -59.
-
5Bruder SP, Jaiswal N, Haynesworth SE. Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subculativation and following cryopreservation. J Cell Biochem 1997; 64(2):278 - 94.
-
6de Wynter EA, Coutinho LH, Pei X, et al. Comparison of purity and enrichment of CD34 + cell of bone marrow, umbilical cord and peripheral blood(primed of apheresis) using five separation systems. Stem Cells 1995: 13: 524- 32.
-
7Reyes M, VerfaiUie CM. Characterization of Multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells. Ann N Y Acad Sci 2001:938:231 -3.
-
8Reyes M, Lund T, Lenvik T, et ai. Purification and ex vivo expansion of postnatal human marrow mesodermal rogenitor cells. Blood 2001; 98:2615 - 25.
-
9Reyes M, Dudek A, Jahagirdar B, et al. Origin of endothelial progenitors in human post-natal bone marrow. J Clin Invest 2002; 109:337 -46.
-
10Schwartz RE, Reyes M, Koodie L, et al. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 2002; 109:1291 - 302.
共引文献74
-
1陈运贤,钟雪云,.骨髓干细胞在再生医学中的临床应用[J].现代医学仪器与应用,2008,0(1):44-48. 被引量:4
-
2王其亮.外周血干细胞移植治疗肝炎后肝硬化临床观察[J].中国实用医药,2007,2(15):79-80. 被引量:3
-
3周汉超,刘黎,周健,田金兰.骨髓、脐血干细胞中淋巴细胞和单核细胞与CD34、CD38亚型细胞百分比在治疗肝硬化中的比较[J].中华临床医师杂志(电子版),2011,5(6):1731-1733. 被引量:14
-
4蒋泽生,高毅,慕宁.人骨髓间充质干细胞亚群ZHJ-MAPCs特征表型及细胞遗传学分析[J].中国临床康复,2006,10(37):4-6.
-
5王海澜,高毅,蒋泽生,慕宁.人骨髓来源多能成体祖细胞ZHJ-MAPCs与人肝细胞系L02体外共培养向肝样细胞的分化[J].世界华人消化杂志,2006,14(23):2294-2300. 被引量:1
-
6刘芳,陈少红,范新娟,唐芳,赵国强.急性肝衰竭模型构建及细胞移植途径初探[J].南华大学学报(医学版),2006,34(4):482-486. 被引量:10
-
7蒋泽生,高毅,慕宁.人骨髓来源多能成体祖细胞与人肝细胞体外直接共培养向肝样细胞分化的实验研究[J].广东医学,2007,28(2):202-204. 被引量:1
-
8蒋泽生,高毅,慕宁.共培养诱导人骨髓多能成体祖细胞分化为肝细胞样细胞[J].中华医学杂志,2007,87(6):414-418. 被引量:5
-
9高毅,蒋泽生,慕宁.人骨髓来源多能成体祖细胞与人肝细胞系体外间接共培养向肝样细胞分化的实验研究[J].中华肝胆外科杂志,2007,13(2):124-127. 被引量:1
-
10柳林,杨海山,孙昱,于世龙.自体脂肪间充质干细胞对晚期肝病影响的初步临床研究[J].中国实验诊断学,2007,11(4):473-476. 被引量:23
同被引文献36
-
1吴理茂,李连达,刘红,宁可永,李贻奎.自体骨髓干细胞移植与归元方联用治疗急慢性肝损伤实验研究[J].中国工程科学,2004,6(7):34-42. 被引量:27
-
2陈秋美.肝硬化伴抑郁症的心理分析及护理[J].浙江临床医学,2005,7(6):668-668. 被引量:4
-
3姚鹏,胡大荣,王帅,闻炜,周一鸣,龚丽娟.自体骨髓干细胞移植治疗慢性肝衰竭研究[J].肝脏,2005,10(3):171-173. 被引量:60
-
4曹伟杰,张萍,徐清芳,张卫东,刘少君,万鼎铭.人骨髓间充质干细胞抑制单核细胞来源的树突状细胞的成熟和功能[J].中原医刊,2006,33(8):7-9. 被引量:3
-
5李婧婷,汪晖,廖长秀,平洁.肝星状细胞激活的分子机制与抗肝纤维化治疗[J].武汉大学学报(医学版),2007,28(2):256-261. 被引量:12
-
6Graft. Differentiation plasticity of hematopoietic cells [J]. Blood, 2002, 99: 3089- 3101.
-
7Malouf NN, Coleman WB, Girsham JW, et al. Adultderived stemcells from the liver becomemyocytes in the heart in vivo [ J]. Am J Patho, 2001, 158:1929 -1935.
-
8du ToitD. Stem cell research [ J]. SADJ, 2006, 61 : 334.
-
9Terai S, Ishikawa T, OmoriK, et al. Improved liver function in patients with liver cirrhosis after autologous bonemarrow cell infusiontherapy [ J ]. Stem Cells, 2006, 24: 2292 - 2298.
-
10Grafl.Differentiation plasticity of hematopojetic cells[J]. Blood,2002,99:3 089-3 101.
引证文献4
-
1刘旭云,赵红艳,张宏文,吴清,傅念.5例自体骨髓干细胞移植治疗肝硬化的护理[J].南华大学学报(医学版),2010,38(5):712-713.
-
2张静.PDCA循环护理干预对自体骨髓干细胞移植治疗肝硬化患者的影响[J].湖南中医药大学学报,2011,31(12):77-79. 被引量:2
-
3徐梅,向国春,刘俐.自体骨髓干细胞移植治疗失代偿期肝硬化的围手术期护理[J].局解手术学杂志,2012,21(1):110-110.
-
4李益飞,牟晓洲,项春生.骨髓间充质干细胞在肝纤维化中的作用[J].中国卫生产业,2013,10(17):189-190.
-
1何春萍,刘黎.自体骨髓干细胞移植术后门静脉血流动力学的变化[J].临床内科杂志,2011,28(6):397-399. 被引量:1
-
2高冬,陈文元,吴立娅,宋军.衰老引发骨髓干细胞演变的规律及中药的干预作用[J].中医杂志,2009,50(1):82-85. 被引量:1
-
3赵宇,仇金霞,王金萍.经冠状动脉自体骨髓单个核细胞移植治疗扩张型心肌病的护理[J].临床护理杂志,2007,6(5):18-19.
-
4晏青,舒畅,廖涌,晏旭,李倩,石贵兰.自体骨髓血干细胞移植治疗术治疗糖尿病足2例护理体会[J].武警医学院学报,2005,14(5):378-379.
-
5石海燕,王立新,王奇,薛炎,邱立成.非体外循环冠状动脉旁路移植术后骨髓干细胞动员的临床研究[J].武警医学,2008,19(9):812-815. 被引量:1
-
6张明鸣,贾贵清,罗婷,杨平,伍晓汀.大鼠骨髓间充质干细胞体外两种分离方法和培养条件下生物学特点的比较[J].华西医学,2009,24(2):371-374. 被引量:13
-
7孙兆明,袁源,潘树茂,张菊华,王媛丽,汤国太,关茂武,陈鸿光.脑源性神经营养因子真核表达载体转染人脐带间充质干细胞[J].中国组织工程研究,2012,16(45):8413-8418. 被引量:1
-
8朱耀凤,刘屹东,宫向欣.自体骨髓干细胞移植术治疗肝衰竭的护理配合[J].中国初级卫生保健,2010,24(7):92-93.
-
9赵庆斌,孙超峰,马爱群,崔长琮,吴岳,田雨灵,赵艳.兔冬眠心肌模型骨髓干细胞动员及心肌组织中肿瘤坏死因子基因表达[J].南方医科大学学报,2009,29(4):711-713. 被引量:1
-
10姚磊,余鹃春.异基因造血干细胞移植人巨细胞病毒感染1例[J].中国感染与化疗杂志,2008,8(2):150-150.