摘要
以1-氯-1-氯乙酰基环丙烷为起始原料,经格式试剂反应、缩合反应、硫的亲电加成反应合成了目标化合物丙硫菌唑,研究了格式试剂反应、缩合反应、硫的亲电加成反应等单元过程的优惠工艺条件。总收率为33.3%,适合工业化应用。
Prothioconazole was synthesized from 1-chloro-acetyl-cyclopropane via Grignard reaction, condensation and electrophlic addition of sulphur powder. The optimum conditions were investigated included the Grignard reaction, condensation and electrophlic addition of sulphur powder. The total yield was up to 33.3 %.
出处
《化工技术与开发》
CAS
2009年第10期21-24,18,共5页
Technology & Development of Chemical Industry