大鼠肝炎性假瘤模型的建立与影像学表现

Establishment of Hepatic Inflammatory Pseudotumor Model in Rats and Analysis of Its Imaging Features

本研究的目的是建立一种可供于影像学研究的大鼠肝炎性假瘤（ＩＰＬ）模型，并研究其影像学的特征。所用的材料和方法是将弗氏佐剂０１ｍｌ／只作大鼠深部注射，１０天后观察大鼠病灶的影像学特征；并取标本做病理检查。结果发现了ＩＰＬ发生率为９０％，大小分别是０３２±０１８ｃｍ。ＩＰＬ的影像学特征表现为强回声结节；ＣＴ平扫为低度圆形影，无强化或仅轻微强化；Ｔ１ＷＩ则呈等或高信号，Ｔ２ＷＩ为略高信号。病理学证实局部肝组织片状坏死并有纤维组织增生及炎细胞浸润。结论是本文研究的大鼠肝炎性假瘤模型具有易建立、容易复制、成功率高、制备周期短和影像学的表现较典型等特点。

Purpose: To establish a model carrying inflammatory pseudotumor of the liver(IPL) in rats serving for medical imaging study purpose, and to analyse its imaging manifestations. Methods: Freund′s complete adjuvant was injected into the desirable portion of the liver at a dose of 0 1 ml per rat (n=20).10 days after the injection, all animals were underwent ultrasound,CT and MRI scans and the findings were analyzed. Then, the lesions were harvested for future pathological examinations. Results: The incidence rate of IPL was 90 0% with the tumor size of 0 32±0 18cm Most of the IPL were identified as hyperechogenic nodules in sonography. In CT,the lesions appeared as well-circumscribed hypodermic areas against the hepatic parenchyma. There was no enhancement or just slight enhacement after injection of iodine contrast agent. In MRI,the lesions were mildly hypo-or iso-intensity on T1 weighted images and hyperintensity on T2 weighted images. Histologically, there was necrotic areas within the nodelules associated with fibrous proliferation and inflammatory cells. Conclusion: The model bearing IPL in rats induced by Freund′s adjuvant, has the advantage of high incidence rate, short latent period, easy duplication and having typical imaging appearances and could be served as ideal experimental animal model for further study of its etiopathology and imaging features.