网状铜丝留置联合平阳霉素注射治疗复杂性海绵状静脉畸形

Treatment of complicated cavernous venous malformation with retained copper wires combined with pingyangmycin injection

目的评价网状铜丝留置结合平阳霉素注射治疗体表软组织内复杂性海绵状静脉畸形的效果。方法通过体检和磁共振检查明确静脉畸形的位置，用直径0．2mm铜丝在畸形血管团内反复穿刺，呈网状留置于畸形病灶内。穿刺结束后向残余畸形血管内注射平阳霉素8cm。8。10d后拔出铜丝，挤出坏死物质，换药至穿刺孔愈合。术后定期行MRI检查，评估疗效。结果2002年1月至2008年12月，共治疗海绵状静脉畸形45例。经1—3年随访，51．1％（23／45）病灶显著缩小甚至接近消失；42．2％（19／45）病灶有所缩小；6．67％（3／45）病灶无明显变化。本组45例均未发生侵袭性感染等并发症。结论网状铜丝留置结合平阳霉素注射是治疗大面积复杂性海绵状静脉畸形的有效方法。

Objective To evaluate the therapeutic effect of retained copper wires combined with pingyangmycin（PYM） injection for complicated cavernous venous malformation. Methods The location of venous malformation was detected by physical examination and MRI. The copper wires in 0.2 mm width were used to puncture the lesion repeatedly and retained in the lesion to form a net. After that, 8 rag PYM was injected into the residue malformed veins. 8 - 10 days later, the copper wires were taken out and necrotic tissue was squeezed out. The wounds of punctual holes healed through dressing. The patients received postoperative MRI to evaluate the therapeutic effect. Results From Jan. 2002 to Dec. 2008, 45 cases were treated. The patients were followed up for 1 - 3 years. 51.1% （23/45） of the lesions shrinked markedly or even disappeared. 42.2% （19/45） of the lesions reduced. 6.67% （3/45） of the lesions didn＇t change. There was no complication like invasive infection. Conclusions It is very effective to treat complicated cavernous venous malformation with retained copper wires combined with pingyangmycin injection.