摘要
The bacillamide 1 is a new algaecide from the marine bacterium Bacillus sp. SY-1. Its analogues bacillamide 3 and alkaloid 4 were firstly synthesized effectively from D-alanine. The key step was a coupling reaction via the mixed anhydride. All structures were confirmed by IH NMR and 13C NMR. The final compounds were confirmed by 1H NMR, 13C NMR and HRMS and the results are consistent with the reported natural products.
The bacillamide 1 is a new algaecide from the marine bacterium Bacillus sp. SY-1. Its analogues bacillamide 3 and alkaloid 4 were firstly synthesized effectively from D-alanine. The key step was a coupling reaction via the mixed anhydride. All structures were confirmed by IH NMR and 13C NMR. The final compounds were confirmed by 1H NMR, 13C NMR and HRMS and the results are consistent with the reported natural products.
基金
the National Science Foundation of China(Nos.20421202,and 20572055) for financial support
