美司钠聚乳酸微球的制备及体外释放

Preparation and in vitro release of mesna polylactic acid microspheres

目的:研究可溶性药物美司钠缓释微球的最佳制备工艺及体外释药,比较O/W溶剂挥发法与W/O/W复乳溶剂挥发法的优缺点。方法:采用乳化-溶剂挥发法制备美司钠聚乳酸微球。由紫外分析法测定微球的药物含量及体外释药量,正交实验确定2种方法的最佳配比。结果:聚乳酸微球具有很好的控释能力。采用W/O/W复乳溶剂挥发法比O/W溶剂挥发法制备的缓释微球在包埋率、载药量和药物释放性能上更好,而O/W法要更简单、经济。找出可溶性药物微球制备工艺最佳配比。

OBJECTIVE To optimize the preparation process and study in vitro release of mesna polylactic acid （PVA） microspheres, and to compare the results of W/O emulsion solvent evaporation and W/O/W emulsion-solvent evaporation. METH- ODS Polylactic acid microspheres were preparedby emulsion-solvent evaporation. Content and amounts of accumulative release in vitro were analyzed using ultraviolet spectrometry. Preparation controlled-release effect of polylactic acid microspheres was good. on the incorporation rate, the loading of drug and the drug release timum preparation process for soluble drug microspheres has been process was optimize by an orthogonal test. RESULTS The Micropheres of prepared by the W/O/W method were better performance. The O/W method to be more simple. The op established.